|
|
Depression in the elderly with focus on people with cognitive deficit
Věchetová, Gabriela ; Hrachovinová, Tamara (advisor) ; Šivicová, Gabriela (referee)
Depressive symptoms are very common among people with neurocognitive disorder. The comorbidity of both diseases and the overlap of their symptoms complicates correct diagnosis and thus also the initiation of a correct treatment. The instruments of depression measuring in seniors with a severe cognitive deficit are also a discussed issue. The subject of the theoretical part is to describe the issue of depression and cognitive disorders in the old age with a focus on Alzheimer's disease, which is the most common mental disorder in the elderly together with depression. The goal of the empirical part of the thesis is to research based on the interviews with seniors if the most frequently used method of depression measuring in the elderly, Geriatric Depression Scale (GDS), is a suitable measuring instrument also in seniors with a cognitive deficit and further examine how these seniors actually experience the individual mood qualities which are the subjects of items in GDS. Forty seniors with a various degree of cognitive deficit participated in the research. The study results showed that the questionnaire is usable for seniors with a mild cognitive impairment and mild dementia. To detect the border of the cognitive deficit, below which it is not suitable to use the depression measuring method GDS, a...
|
|
| |
|
|
Effects of Neurotransmission-Modulating Multipotent Compounds in Pharmacological Animal Models of Cognitive Deficit
Chvojková, Markéta ; Valeš, Karel (advisor) ; Kuchař, Martin (referee) ; Rudá, Jana (referee)
In preclinical research on Alzheimer's disease pharmacotherapy, attention is paid to multipotent compounds, enabling intensification of the effect by targeting multiple pathophysiological mechanisms. The aim of the thesis was to assess the effect of multipotent compounds and combination therapy in models of cognitive deficit in the rat. The mechanism of action of the tested compounds was modulation of neurotransmitter systems. The aim of the first part of the study was to compare the effect of experimental monotherapy and combination therapy with an N-methyl-D-aspartate (NMDA) receptor antagonist and a γ-aminobutyric acid type A (GABAA) receptor positive modulator in the trimethyltin-induced model. Superiority of the combination therapy was proven by histological analysis of hippocampal neurodegeneration; however, it did not reach statistical significance in the cognitive test. The other part of the thesis focused on multipotent tacrine derivatives. We demonstrated a positive effect of 6- chlorotacrine-6-nitrobenzothiazole hybrid, as well as 6-chlorotacrine-L-tryptophan hybrid, acting as acetylcholinesterase inhibitors, in the scopolamine-induced model of cognitive deficit. Besides, we demonstrated a low risk of serious side effects of other tacrine derivatives acting as NMDA receptor antagonists....
|
|
|
Treatment for Brain Arteriovenous Malformations
Bradáč, Ondřej ; Beneš, Vladimír (advisor) ; Haninec, Pavel (referee) ; Vaverka, Miroslav (referee)
Introduction: The surgical and endovascular results of the treatment of pial AVM provided at our Neurosurgical centre are presented. These results are supported by neuropsychological outcomes of subgroup of treated patients. Going by these results and by an overview of literary data on the efficacy and complications of each therapeutic modality, the optimal algorithm of indications is presented Cohort of patients: The main series comprises 222 patients aged 9 to 87 years treated in the years 1998 - 2013. The surgical group consists of 85 patients, 55 patients received solely endovascular treatment. Thirty-four patients were consulted and referred directly to the Radiosurgical unit. The remaining 48 were recommended to abide by the strategy of "watch and wait". A subgroup of 66 patients, who underwent treatment of AVM was neuro-psychologically tested at least two years after treatment using a battery of tests constructed specifically for this study. A control group consisted of 10 subjects without any neurological disease. Results: In the surgical group, serious complications were 3.5% at a 96.5% therapeutic efficacy. As for AVM treated with purely endovascular methods, serious procedural complications were seen in 5.5% of patients, with efficacy totalling 36.4%. One observed patient suffered...
|
|
|
Functional consequences of perinatal hypoxia-ischemia in rat
Nováková, Eva ; Otáhal, Jakub (advisor) ; Riljak, Vladimír (referee)
Title: Functional consequences of perinatal hypoxia-ischemia in rat Objectives: The aim of this diploma thesis is to design a set of behavioral tests which provide an effective assessment of motor and cognitive-behavioural deficits in adults rats after experimental hypoxic-ischemic insult during the perinatal period (P7). Supposed benefit is to establish a model of motor and cognitive-behavioural abilities of individuals after this procedure. Methods: The present thesis has a theoretical-empirical character. The practical part describes how the experiment was performed. 32 long Evans Rats were randomly devided into two groups: experimental group (HIE) and control group (Ctrl). The method to produce hypoxic-ischemic brain damage in the 7 day-old rats consisted of right common carotid ligation followed by systemic hypoxia by the inhalation of 8% oxygen and 92% nitrogen. The adult animals (55-75 days old) were tested by the following list of behavioral tests: Bar holding test, Rotarod test, Ladder rung walking test, Reaching test, Open field test and Morris water maze test. Sigma Plot and Microsoft Excel 2010 were the programs used for statistical analysis. Results: Results of Open field test, Ladder rung walking test and Morris water maze test confirmed that hypoxic-ischemic insult affects the...
|
|
|
Nursing care of a patient with iatrogenic perforation of oesophagus
Polívková, Helena ; Di Cara, Veronika (advisor) ; Hocková, Jana (referee)
The theme of the final thesis is the nursing process in a patient with iatrogenic perforation of the esophagus in the Department of Geriatric Medicine. I consider the chosen topic to be very interesting, but not too often presented from the viewpoint of a nurse and nursing. Based on a single patient case study, the objective was to analyze the care provided for a patient with iatrogenic perforation of the esophagus in the Department of Geriatric Medicine. Nursing care was focused on the care of a geriatric patient with an esophagostomy, mediastinal drain and cognitive deficits. Another goal was to demonstrate that even in the geriatric department, very good results can be achieved by providing a good patient care. The last objective was to compare the procedures provided by nursing care in the Czech Republic and abroad. In my final thesis, I used a case study method, implemented by a nursing case in a patient in the geriatric department and aftercare of a regional type medical facility. Information for the final thesis was drawn from Czech and foreign literature, own observation and provision of nursing care, interview with the patient and from its available documentation. Part of the information was obtained from an interview with the medical team that provided the care. I had the oral approval of...
|
|
|
Evaluation of Psychometric Characteristics of Czech Version RBANS
Brodská, Veronika ; Krámská, Lenka (referee) ; Kulišťák, Petr (referee)
The thesis deals with the Czech version of the original American neuropsychological battery RBANS (i.e. Repeatable Battery for the Assessment of Neuropsychological Status). There are two objectives of the thesis: verifying the test-retest stability and assessment of the equivalency of the two alternate forms, form A and B of the Czech version of the RBANS. The theoretical part deals with neuropsychological diagnostics and its methods, it also presents a neuropsychological battery RBANS, describes a test method, testing materials and organization of the scale, and it reminds RBANS use in clinical practice through a number of foreign studies. The practical part analyse data that were obtained from the group of 46 healthy volunteers aged between 20 and 77 years by repeated administration of the method. The time period between test and retest was 1 month. The test-retest stability was evaluated by the coefficient of stability and the equivalence of forms A and B by a coefficient of equivalence. Furthermore, there were evaluated possible correlations with the level of education and age. The test-retest coefficients of stability were in total score of 0.75 and 0.71 and they ranged from 0.43 to 0.85 in indexes; and equivalence coefficients were in total score of 0.72 and 0.71 and they ranged from 0.43 to 0.87 in...
|
|
|
Assessment of cognitive impairment in schizophrenic patients
Kuhnová, Eva ; Hrachovinová, Tamara (advisor) ; Loneková, Katarína (referee)
The thesis deals with the contemporary topic of cognitive deficit present by schizophrenic people. It introduces the subjective point of view of the patients in more detail, which means the experience of deficits in the cognitive area. The text itself consists, as usual, of the theoretical and the research section. The theoretical section deals with the specifics of cognitive functions and their deficits present by schizophrenic patients. It focuses more closely on the subjective point of view of an individual, the impairment-related experience which follows from the impaired cognitive functions. The thesis pursues also the impact of cognitive impairment on an individual's life. A part of the theoretical section is also dedicated to the tools designated to measure cognitive functions. The major subpart is dedicated to self-evaluating tool entitled Frankfurt Complaint Questionnaire (FCQ), concerning primarily its origin, description and psychometric properties. The research section is based on the usage of the Czech translation of the FCQ in practice. Based on an observation of a sample of 53 individuals diagnosed with F20.0 and 53 healthy people, the psychometric qualities of the FCQ (discriminant validity, Cronbach's alpha, test-retest reliability) were examined. In case of patients diagnosed with...
|
|
|
Cognitive functioning in everyday life in patients with Borderline personality disorder
Krupníková, Hana ; Stehlík, Luděk (referee) ; Niederlová, Markéta (referee)
This thesis focuses on cognitive function in everyday life with an emotionally unstable personality disorder, border type and builds on the thesis, which was defended in 2011. The theoretical part deals with the cognitive functions that have a selective approach in terms of importance within the research project. Chapters on borderline personality disorder contain an overview of the historical development of diagnosis, the diagnosis and further elaborate on diagnostic models of Kernberg and Millon. Both studies link the topics that deal with cognitive functions in individuals with this disorder. In the empirical part, which describes the research project, approaching test methods used. We try to verify the relationship between diagnosed emotionally unstable personality disorder (IPDE questionnaire) and cognitive functions in everyday life using ANT and questionnaires MFQ, CFFQ and MIA in the research and control group. The relationship of cognitive functions and subjective measured depressive symptoms is studied using the BDI-II and MADRS. The research project is complemented by secondary analysis of our research project and Klára Patlichová research project focused on comparing the results of the attention test ANT. This thesis is enhanced by a qualitative part of case studies. Key words:...
|
|
|
Treatment for Brain Arteriovenous Malformations
Bradáč, Ondřej ; Beneš, Vladimír (advisor) ; Haninec, Pavel (referee) ; Vaverka, Miroslav (referee)
Introduction: The surgical and endovascular results of the treatment of pial AVM provided at our Neurosurgical centre are presented. These results are supported by neuropsychological outcomes of subgroup of treated patients. Going by these results and by an overview of literary data on the efficacy and complications of each therapeutic modality, the optimal algorithm of indications is presented Cohort of patients: The main series comprises 222 patients aged 9 to 87 years treated in the years 1998 - 2013. The surgical group consists of 85 patients, 55 patients received solely endovascular treatment. Thirty-four patients were consulted and referred directly to the Radiosurgical unit. The remaining 48 were recommended to abide by the strategy of "watch and wait". A subgroup of 66 patients, who underwent treatment of AVM was neuro-psychologically tested at least two years after treatment using a battery of tests constructed specifically for this study. A control group consisted of 10 subjects without any neurological disease. Results: In the surgical group, serious complications were 3.5% at a 96.5% therapeutic efficacy. As for AVM treated with purely endovascular methods, serious procedural complications were seen in 5.5% of patients, with efficacy totalling 36.4%. One observed patient suffered...
|
guest ::
